In what scenarios is AA most useful?

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Application acceleration is most useful in networks where applications are experiencing problems with high latency.

For example:

WANs that cannot support applications performance due to latency or traffic load including inter-continental and satellite links
Sites separated by large geographical distances
Environments with unpredictable performance
Remote Disaster Recovery environments where large data backups are done overnight
Environments that are consolidating server infrastructure into central location and need to ensure WAN users have satisfactory application response times.